In addition, dosage monitoring will also benefit the RFID (Radio Frequency Identification) platform enabled personalized medical tracking and chronic disease management. Drug delivery systems may have different control mechanisms –, but no matter what control mechanism is adopted, drug dosage monitoring is crucial to provide feedback as well as prevent unexpected in-vivo fluctuation and leakage. Instead of injecting drugs at the maximum tolerable dose (MTD) once in a treatment period, contemporary drug delivery paradigms maintain the constant release and administer it within some desired therapeutic range, providing minimized side effects and increased therapeutic efficacy. I. Introduction DRIVEN by the rise of micro and nano technologies, controlled rate and micro-patterned drug deliveries have been playing major roles to overcome the limitations of conventional burst-release dosage forms. The in vitro experiment on two prototypes of antenna sensor-drug reservoir assembly have shown the ability to monitor the drug dosage by tracking antenna resonant frequency shift from 2.4–2.5-GHz ISM band with realized sensitivity of 1.27 for transdermal drug delivery monitoring and 2.76- sensitivity for implanted drug delivery monitoring.
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